منابع مشابه
Erythromycin inhibits Cl secretion across canine tracheal epithelial cells.
We studied the effect of the macrolide antibiotic erythromycin on bioelectrical properties of canine cultured tracheal epithelium under short-circuit conditions in vitro. Addition of erythromycin to the submucosal but not to the mucosal side dose-dependently decreased short-circuit current (Isc), the maximal decrease from the baseline value and the concentration required to produce a half-maxim...
متن کاملSimulation of Cl− Secretion in Epithelial Tissues: New Methodology Estimating Activity of Electro-Neutral Cl− Transporter
Transcellular Cl(-) secretion is, in general, mediated by two steps; (1) the entry step of Cl(-) into the cytosolic space from the basolateral space across the basolateral membrane by Cl(-) transporters, such as Na(+)-K(+)-2Cl(-) cotransporter (NKCC1, an isoform of NKCC), and (2) the releasing step of Cl(-) from the cytosolic space into the luminal (air) space across the apical membrane via Cl(...
متن کاملDistinct Action of Flavonoids, Myricetin and Quercetin, on Epithelial Cl− Secretion: Useful Tools as Regulators of Cl− Secretion
Epithelial Cl(-) secretion plays important roles in water secretion preventing bacterial/viral infection and regulation of body fluid. We previously suggested that quercetin would be a useful compound for maintaining epithelial Cl(-) secretion at a moderate level irrespective of cAMP-induced stimulation. However, we need a compound that stimulates epithelial Cl(-) secretion even under cAMP-stim...
متن کاملErythromycin inhibits Cl secretion
We read with interest the report of erythromycin reducing chloride secretion in canine tracheal epithelium (1]. However, we would like to caution against extrapolating from dog to man. Canine trachea is virtually unique in its ion transport properties predominantly secreting chloride, a process which is stimulated by endogenous prostaglandin synthesis. The shortcircuit current of human airways ...
متن کاملActivation of the basolateral membrane Cl- conductance essential for electrogenic K+ secretion suppresses electrogenic Cl- secretion.
Adrenaline activates transient Cl(-) secretion and sustained K(+) secretion across isolated distal colonic mucosa of guinea-pigs. The Ca(2+)-activated Cl(-) channel inhibitor CaCCinh-A01 (30 μm) significantly reduced electrogenic K(+) secretion, detected as short-circuit current (I(sc)). This inhibition supported the cell model for K(+) secretion in which basolateral membrane Cl(-) channels pro...
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ژورنال
عنوان ژورنال: Experimental Physiology
سال: 1993
ISSN: 0958-0670
DOI: 10.1113/expphysiol.1993.sp003674